Left ventricle structure and function as evaluated by echocardiography in both wild-type (WT) and melusin null mice subjected to transverse aortic constriction. Representative M-mode left ventricular echocardiografic recordings of wild-type (upper pictures) and melusin-null (lower pictures) mice in basal conditions or after 2 and 4 weeks of aortic constriction are shown.

Note the left ventricle chamber dilation occurring in heart of melusin null mice (lower panels).